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Alan W Flake Selected Research

Meningomyelocele (Myelomeningocele)

1/2020Benchmarking against the MOMS Trial: Zurich Results of Open Fetal Surgery for Spina Bifida.
1/2018Amniotic Fluid Concentrations of Glial Fibrillary Acidic Protein Do Not Correlate with Prenatal Metrics in Fetuses with Myelomeningocele.
1/2017Establishing Prenatal Surgery for Myelomeningocele in Asia: The Singapore Consensus.
12/2013Premiere use of Integra™ artificial skin to close an extensive fetal skin defect during open in utero repair of myelomeningocele.
2/2011Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury.
5/2010A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor.
1/2008Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele.
1/2007Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele.

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Alan W Flake Research Topics

Disease

13Congenital Diaphragmatic Hernias
09/2018 - 10/2002
8Pulmonary Hypertension
11/2021 - 06/2005
8Meningomyelocele (Myelomeningocele)
01/2020 - 01/2007
5Body Weight (Weight, Body)
10/2016 - 09/2003
4Diaphragmatic Hernia
11/2021 - 04/2005
4Hemorrhage
01/2020 - 03/2002
4Edema (Dropsy)
01/2016 - 03/2002
4Airway Obstruction (Choking)
10/2013 - 03/2002
3Inborn Genetic Diseases (Disease, Hereditary)
01/2020 - 08/2002
3Gastroesophageal Reflux (GERD)
10/2018 - 03/2015
3Autistic Disorder (Autism)
03/2017 - 04/2010
3Birth Weight (Birth Weights)
12/2014 - 03/2004
3Hemophilia B (Haemophilia B)
03/2012 - 04/2003
3Muscular Dystrophies (Muscular Dystrophy)
09/2004 - 01/2002
2Sickle Cell Anemia (Hemoglobin S Disease)
01/2020 - 11/2017
2Graft vs Host Disease (Graft-Versus-Host Disease)
01/2018 - 03/2004
2Protein Deficiency
06/2016 - 01/2015
2Vesicular Stomatitis
06/2014 - 09/2002
2Rupture
01/2014 - 10/2004
2Neoplasms (Cancer)
10/2013 - 01/2005
2Teratoma (Teratoid Tumor)
06/2012 - 10/2002
2Cholestasis
09/2010 - 07/2006
2Biliary Atresia
09/2010 - 07/2006
2Gastroschisis
07/2010 - 01/2002
2Thrombotic Thrombocytopenic Purpura
03/2009 - 01/2009
2Cicatrix (Scar)
06/2008 - 03/2002
2Congenital Cystic Adenomatoid Malformation of Lung (Cystic Adenomatoid Malformation of Lung)
01/2007 - 03/2002
2Congenital Abnormalities (Deformity)
06/2005 - 06/2003
2Polyhydramnios
06/2005 - 01/2005
2Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
12/2004 - 10/2002
1Brain Injuries (Brain Injury)
05/2022
1Fetal Growth Retardation (Intrauterine Growth Retardation)
11/2021
1Acidosis
11/2021
1Hypoxia (Hypoxemia)
01/2020
1Congenital Heart Defects (Congenital Heart Defect)
01/2020
1Hydrocephalus (Hydrocephaly)
10/2019
1Hematologic Diseases (Blood Diseases)
01/2019
1Anemia
01/2019
1Fetal Hypoxia
12/2018
1Necrosis
10/2018
1Hiatal Hernia
10/2018
1Intestinal Atresia
10/2018
1Respiratory Insufficiency (Respiratory Failure)
08/2018
1Fetal Death
11/2017
1Hearing Loss (Hearing Impairment)
03/2017
1Cystic Fibrosis (Mucoviscidosis)
06/2016
1Lung Diseases (Lung Disease)
06/2016
1Wounds and Injuries (Trauma)
02/2016
1Hyperbilirubinemia
01/2016
1Familial duodenal atresia
01/2016
1Umbilical Hernia (Omphalocele)
09/2015
1Hypertension (High Blood Pressure)
09/2015
1Failure to Thrive
03/2015

Drug/Important Bio-Agent (IBA)

6Proteins (Proteins, Gene)FDA Link
02/2011 - 09/2003
5Oxygen (Dioxygen)IBA
01/2020 - 02/2003
4Tretinoin (Retinoic Acid)FDA LinkGeneric
09/2018 - 01/2007
4nitrofenIBA
09/2018 - 10/2003
4Surface-Active Agents (Surfactants)IBA
06/2016 - 04/2005
3Sildenafil Citrate (Viagra)FDA Link
11/2021 - 06/2016
3Betamethasone (Celestone)FDA Link
01/2016 - 06/2005
3Factor IX (Coagulation Factor IX)FDA LinkGeneric
03/2012 - 04/2003
2Biomarkers (Surrogate Marker)IBA
05/2022 - 02/2015
2Glial Fibrillary Acidic ProteinIBA
01/2018 - 02/2011
2Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2016 - 12/2014
2SteroidsIBA
01/2016 - 01/2007
2Glycoproteins (Glycoprotein)IBA
06/2014 - 09/2002
2thiamine triphosphorate (TTP)IBA
03/2009 - 01/2009
2ferric chlorideIBA
03/2009 - 01/2009
2GlucocorticoidsIBA
12/2006 - 08/2006
2Messenger RNA (mRNA)IBA
12/2006 - 04/2005
2salicylhydroxamic acid (SHAM)IBA
04/2006 - 01/2002
2DNA (Deoxyribonucleic Acid)IBA
10/2003 - 09/2003
1Pharmaceutical PreparationsIBA
01/2020
1Investigational DrugsIBA
01/2020
1ErythropoietinFDA Link
01/2019
1Imatinib Mesylate (Gleevec)FDA Link
09/2018
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2016
1EnzymesIBA
01/2016
1Antihypertensive Agents (Antihypertensives)IBA
09/2015
1CreatinineIBA
09/2015

Therapy/Procedure

17Therapeutics
01/2020 - 08/2002
10Extracorporeal Membrane Oxygenation
01/2020 - 03/2002
6Ex utero Intrapartum Treatment Procedures
10/2013 - 03/2002
5Tracheostomy
03/2017 - 04/2010
4Cell Transplantation
01/2020 - 12/2004
4Enteral Nutrition (Feeding, Tube)
01/2018 - 04/2008
4Length of Stay
04/2008 - 03/2002
3Mechanical Ventilators (Ventilator)
01/2018 - 04/2008
3Resuscitation
01/2018 - 06/2005
3Fetal Therapies (Fetal Therapy)
01/2017 - 10/2002
3Cesarean Section (Caesarean Section)
10/2004 - 03/2002
2Hepatic Portoenterostomy
09/2010 - 07/2006
2Operative Time
06/2008 - 10/2006
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
02/2003 - 01/2002
1Ventriculostomy
10/2019
1Ventriculoperitoneal Shunt
10/2019
1Transplantation
01/2019
1Fundoplication
10/2018
1Negative-Pressure Wound Therapy
02/2016
1Duodenostomy
01/2016